Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
This position is full-time and works approximately 40 hours per week.
Post Doc Instructions:
Please do not submit an application to this posting. To apply for this postdoctoral research opportunity, follow the directions below in “Applicant Special Instructions”.
Department Name/Job Location:
This position is in the Department of Surgery, Division of Gynecologic Oncology. This position is for the Medical School Campus.
The Spitzer Lab is looking for an enthusiastic scientist who is passionate about creating the next generation of targeted protein-based immunotherapeutics. Our research is focused on the development and clinical translation of targeted TRAIL-based cancer biologics (REFs). Current projects in the lab center on the development and engineering of (scFv) antibody fusion proteins being used in single-agents trials as well as in combination with other cancer-targeted biologics/small molecules. The created compounds will be tested in vitro and in preclinical mouse models of ovarian and/or pancreatic cancer and lead candidates will be optimized for clinical translation. The ideal candidate should be highly experienced in scFv antibody/protein drug discovery as well as engineering and share our vision for the development of next-generation immunoproteins.
PRIMARY DUTIES AND RESPONSIBILITIES:
Develop and execute strategies to engineer proteins that strongly and specifically bind a desired target using molecular biology and high-throughput screening techniques.
Utilize protein purification techniques and analytical methods to characterize proteins of interest.
Participate in grant/manuscript/presentation preparation.
Advance research projects through synergistic interactions with both other lab members and collaborators.
Base pay commensurate with experience.
Prior experience in molecular biology is essential. Additional experience in basic functions of the immune system will be an asset. Other qualifications include a Ph.D. and/or M.D. degree and a strong publication track record.
First author publication(s) in protein engineering or relevant field; broad knowledge of protein engineering strategies.
Track-record of productive biochemical lab experience including cloning, protein expression (bacterial and/or mammalian), protein purification, and/or biophysical characterization.
Experience with phage display, yeast display or similar molecular evolution-based approaches.
Experience with in vivo mouse studies.
Enjoy taking calculated risks and operating with urgency.
Additional experience/knowledge in (cancer) immunology and immune system will be an asset.
This position is eligible for full-time benefits.� Please visit our website at http://hr.wustl.edu to view a summary of benefits.
Applicant Special Instructions:
Please email a cover letter, CV, and a list of three references to Dr. Dirk Spitzer at email@example.com.
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.
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